Metabolic profiling of COVID-19 severity and mortality: A targeted metabolomics approach

Abstract The analysis of metabolites in response to SARS-CoV-2 infection provides a snapshot the endogenous host metabolism and its role shaping interaction with SARS-CoV-2. In this study, using targeted metabolomics approach, metabolic signatures severity mortality were studied COVID-19 patients. Our revealed survival severity-associated shifts metabolome patients, where amino acids, particularly tryptophan arginine, fatty acid altered severe patients as compared mild asymptomatic cases. Herein, we also report alterations sums ratios several essential acids well kynurenine ratio, which is an indicator indoleamine-2,3-dioxygenase (IDO) activity. findings suggest that creatine including symmetric dimethylarginine, asymmetric 1-methylhistidine can be used biomarkers identify at risk poor outcomes COVID-19, lower levels these are associated higher probabilities. Additionally, elevated short chain acylcarnitines carnitine palmitoyltransferase 1 2 enzymes indicators have been observed critically ill indicating their potential usefulness predictors hospital outcome, likely due increased demand for energy, inflammation, mitochondrial dysfunction. improve our understanding disease by providing insight into relationship between progression, lead development therapeutics clinical models. This work was supported Emergency Response Grant ID: 252